PERFLUORO ALKYL GROUP-CONTAINING NUCLEIC ACID AND PRODUCTION METHOD THEREFOR

PERFLUORO ALKYL GROUP-CONTAINING NUCLEIC ACID AND PRODUCTION METHOD THEREFOR

To provide a nucleic acid excellent in cell membrane permeability and a method for its production.A nucleic acid containing a C2-10 perfluoroalkyl group having from 1 to 5 ether-bonding oxygen atoms between carbon atoms; said nucleic acid wherein said perfluoroalkyl group is directly or indirectly b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: AIKAWA Kohsuke, MORIHIRO Kunihiko, OKAMOTO Akimitsu, OKAZOE Takashi, ISHIBASHI Yuichiro, WATANABE Honoka
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:To provide a nucleic acid excellent in cell membrane permeability and a method for its production.A nucleic acid containing a C2-10 perfluoroalkyl group having from 1 to 5 ether-bonding oxygen atoms between carbon atoms; said nucleic acid wherein said perfluoroalkyl group is directly or indirectly bonded to the 5'- or 3'-end of the nucleic acid, or said perfluoroalkyl group is indirectly introduced between two nucleotides; or a nucleic acid medicine comprising, as an active ingredient, a nucleic acid containing a C2-10 perfluoroalkyl group, which may have from 1 to 5 ether-bonding oxygen atoms between carbon atoms.