THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF

THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF

The present invention relates to a group of compounds of formula (I):which are inhibitors of the Discoidin Domain Receptors (DDR1/2), whose overexpression is produced in several diseases such as cancer, pulmonary fibrosis, cirrhotic liver, liver fibrosis, lupus nephritis, osteoarthritis, rheumatoid...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PASTOR FERNÁNDEZ, Joaquín, GARCÍA CAMPOS, FRANCISCO JAVIER, BLANCO-APARICIO, Carmen, MARTÍNEZ GONZÁLEZ, Sonia
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a group of compounds of formula (I):which are inhibitors of the Discoidin Domain Receptors (DDR1/2), whose overexpression is produced in several diseases such as cancer, pulmonary fibrosis, cirrhotic liver, liver fibrosis, lupus nephritis, osteoarthritis, rheumatoid arthritis and atherosclerosis, so the compounds of the invention are useful for the treatment of said diseases.