SPORE-BASED PROBIOTIC COMPOSITION FOR MODULATION OF MICROBIOME IN HUMANS

A spore-based probiotic composition is provided that comprises at least one viable probiotic microorganism having a biological or therapeutic effect on microbiome in humans. One exemplary composition contains five different strains of Bacillus spp. Also provided are methods of producing spore-based...

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Bibliographische Detailangaben
Hauptverfasser:	KRIZ, Dale, M, BAYNE, Thomas, F, KRISHNAN, Kiran
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A spore-based probiotic composition is provided that comprises at least one viable probiotic microorganism having a biological or therapeutic effect on microbiome in humans. One exemplary composition contains five different strains of Bacillus spp. Also provided are methods of producing spore-based probiotic compositions. A validated in vitro gut model which is a simulated human intestinal microbial ecosystem reactor was used to assess the long-term effect of the composition on microbial metabolic activity and community composition. The results support use of the composition in protecting against obesity-related disorders, metabolic disorders, inflammation, and cancer, for example. A method for modulating microbial metabolic activity and/or modulating microbial community composition in a human subject is described.