TRICYCLIC JANUS KINASE (JAK) INHIBITORS AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES

TRICYCLIC JANUS KINASE (JAK) INHIBITORS AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES

The present invention relates to compounds of formula 1 or 2,wherein R1 and R3 are purine or a purine analog and R2 and R4 are a small functional group. The invention also relates to intermediates of the synthesis of compounds of formula 1 or 2. Compounds of formula 1 or 2 are Janus kinase inhibitor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: REYMOND, Jean-Louis, MEIER, Kris
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula 1 or 2,wherein R1 and R3 are purine or a purine analog and R2 and R4 are a small functional group. The invention also relates to intermediates of the synthesis of compounds of formula 1 or 2. Compounds of formula 1 or 2 are Janus kinase inhibitors and thus useful in the treatment of a disease, particularly an autoimmune disease, cancer, Alzheimer's disease or useful in preventing the rejection of an allograft or xenograft.