METHOD FOR PRODUCING PEPTIDE COMPOUND

A task of the present invention is to provide a method for producing a peptide at high efficiency. In the present invention, there is provided a method for producing a peptide, which comprises the steps of:(1) removing the N-terminal protective group of an amino acid or peptide compound represented by the formula (I):wherein Y represents a residue of an N-protected amino acid or an N-protected peptide, andeach of R1, R2, and R3 independently represents an aliphatic hydrocarbon group which may have a substituent (in which each of 1 to 5 methylene groups in the aliphatic hydrocarbon group may be independently replaced by a structure selected from the group consisting of -O-, -CO-, -N(R6)-, -N(R7)CO-, and -CON(R8)-) or an aromatic hydrocarbon group which may have a substituent, wherein each of R6, R7, and R8 independently represents a hydrogen atom or a C1-6 alkyl group,wherein the total number of carbon atoms in the R1R2R3Si group is 18 to 80, andthe R1R2R3SiCH2CH2 group is bonded to the C-terminus of the amino acid or peptide residue in Y;and(2) causing condensation of an N-protected amino acid or an N-protected peptide and the N-terminus of the C-protected amino acid or C-protected peptide obtained in the step (1).