SALT AND CRYSTAL FORMS OF AN ACTIVIN RECEPTOR-LIKE KINASE INHIBITOR

SALT AND CRYSTAL FORMS OF AN ACTIVIN RECEPTOR-LIKE KINASE INHIBITOR

Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are cha...

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Bibliographische Detailangaben
Hauptverfasser: MAZAIK, Debra, WAETZIG, Joshua D, HEINRICH, Brian, JOHNSTON, Steven C, WILKIE, Gordon, OHMER, Harald, MEDENDORP, Clare, SIEGEL, Dominik, MACEACHERN, Lauren
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject.