METHOD TO ISOLATE TCR GENES

The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. In some embodiments, the methods disclosed are used for cancer immunothera...

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Bibliographische Detailangaben
Hauptverfasser:	KUILMAN, Thomas, SCHUMACHER, Antonius, Nicolaas, Maria, BENDLE, Gavin, M, GADIOT, Jules, F.C, GOMEZ-EERLAND, Raquel, LINNEMANN, Carsten, VAN HEIJST, Jeroen, W.J, SCHRIKKEMA, Deborah, Sophie
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ARTIFICIAL STONE BEER BIOCHEMISTRY CEMENTS CERAMICS CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDINGMATERIALS CONCRETE CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES LIME, MAGNESIA MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS REFRACTORIES SLAG SPIRITS TREATMENT OF NATURAL STONE VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. In some embodiments, the methods disclosed are used for cancer immunotherapy or diagnostic purposes.