MIR-124 AS A BIOMARKER FOR THE TREATMENT OF INFLAMMATORY DISEASES

The present invention relates to An in vitro or ex vivo use of at least one miRNA, said at least one miRNA being miR-124, as a biomarker for screening a quinoline derivative and in particular a compound of formula (I), presumed effective in treating and/or preventing an inflammatory disease, wherein...

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Bibliographische Detailangaben
Hauptverfasser:	SCHERRER, Didier, NAJMAN, Romain, TAZI, Jamal, MAHUTEAU, Florence
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to An in vitro or ex vivo use of at least one miRNA, said at least one miRNA being miR-124, as a biomarker for screening a quinoline derivative and in particular a compound of formula (I), presumed effective in treating and/or preventing an inflammatory disease, wherein formula (I) is defined herein afterwherein Z is C or N, V is C or N,means an aromatic ring wherein V is C or N and when V is N, V is in ortho, meta or para of Z; R independently represent a hydrogen atom, a methyl group, a methoxy group, a trifluoromethyl group, a trifluoromethoxy group, an amino group, a halogen atom and a -O-P(=O)-(OR3)(OR4) group; R' independently represent a hydrogen atom, a halogen atom, an amino group, a methyl group, a -O-P(=O)-(OR3)(OR4) group or a groupand Q is N or O.The present invention further relates to a method for assessing and following the efficacy of said compound of formula (I), comprising the measurement of the presence or level of expression of miR-124 into an isolated biological sample.