CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT

The present disclosure relates generally to antibodies reactive with tumor-specific neoantigens, as well as neoantigen-binding fragments thereof. The present disclosure also relates to nucleic acids, expression cassettes, and expression vectors encoding the antibodies and neoantigen-binding fragment...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG, Ziyang, ROHWEDER, Peter J, SHOKAT, Kevan M, CRAIK, Charles S
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present disclosure relates generally to antibodies reactive with tumor-specific neoantigens, as well as neoantigen-binding fragments thereof. The present disclosure also relates to nucleic acids, expression cassettes, and expression vectors encoding the antibodies and neoantigen-binding fragments. The antibodies and neoantigen binding-fragments are useful for diagnosis and treatment of cancer.