NOVEL FUNCTIONALIZED HYDROGEL COATINGS OF ASSAY PLATES AND USES THEREOF

The present invention relates to the field of microplate assay-based analytical and diagnostic applications, in particular immunoaffinity assays, ELISA or ELISpot assays. More specifically, the present invention relates to functionalized hydrogel coatings of assay plates. The present invention provi...

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Bibliographische Detailangaben
Hauptverfasser:	STEINER, Mark-Steven, RÜHE, Jürgen, STRAUB, Alexander Johannes, SCHERAG, Frank Daniel, KIND, Martin, BRANDSTETTER, Thomas
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL PROCESSES OF COMPOUNDING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP TRANSPORTING VINEGAR WINE WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to the field of microplate assay-based analytical and diagnostic applications, in particular immunoaffinity assays, ELISA or ELISpot assays. More specifically, the present invention relates to functionalized hydrogel coatings of assay plates. The present invention provides a novel method of manufacturing a surface-bonded continuous layer of a copolymer that can be applied to assay plates used in analytical or diagnostic applications. The copolymer is characterized in that it comprises at least three different monomer units and includes at least one photo-reactive side group for a C, H-insertion cross-linking ["CHic"] reaction; and at least one click binding-reactive side group ["Click"] for (bio-) functionalizing of the copolymer layer. Furthermore, the present invention provides containers having such a novel surface-bonded continuous layer of a copolymer, as well as uses thereof for the selective attachment and/or capturing of biochemical reagents to the copolymer layer.