COMBINATION THERAPY METHODS, COMPOSITIONS AND KITS

Combination therapy methods, compositions and kits Invention relates to combinations comprising: a) a compound of formula (I)or a pharmaceutically or veterinary acceptable salt thereof, wherein:R1 R2 and R3 have particular meaning; and (b) one or more drugs selected from the group consisting of i) a...

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1. Verfasser: VILLOSLADA DIAZ, Pablo
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Combination therapy methods, compositions and kits Invention relates to combinations comprising: a) a compound of formula (I)or a pharmaceutically or veterinary acceptable salt thereof, wherein:R1 R2 and R3 have particular meaning; and (b) one or more drugs selected from the group consisting of i) a compound of formula (IV), or a pharmaceutically or veterinary acceptable salt thereof,wherein R5 and R6 have particular meaning, ii) a sphingosine-1-phosphate receptor inhibitor (S1PR modulator), and iii) a Signal transducer and activator of transcription 3 (STAT3) inhibitor. Particular combinations and single pharmaceutical compositions and kits of parts are disclosed. These combinations, single pharmaceutical compositions and kits of parts are for use in the treatment and/or prevention of an inflammatory neurological disease or condition which can result in the destruction or degeneration of axons or myelin in a subject in need thereof