FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS

A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ZHU, Zhaoning, TAYLOR, Richard David, HORSLEY, Helen Tracey, CHU, Shuyu, MONCK, Nathaniel Julius Thomas, BRACE, Gareth Neil, CHAPPELL, Rose Elizabeth, CHOVATIA, Prafulkumar Tulshibhai, REUBERSON, James Thomas, HASLETT, GREGORY WILLIAM, SMALLEY, Adam Peter
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C-R1 or N; B represents C-R2 or N; D represents C-R3 or N; E represents C-R4 or N; Z represents -CH(R5)N(H)CH2R6, -CH(R5)N(H)S(O)2R6, -C(═CR5aR5b)N(H)C(O)R6, -CH(R5)R7, -CH(R5)N(H)R7 or -CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.