SORCS2 CRYSTAL STRUCTURE AND USES THEREOF

SORCS2 CRYSTAL STRUCTURE AND USES THEREOF

The present invention relates to a SorCS2 crystal structure, the atomic coordinates obtained by X-ray crystallography of same, and their use in molecular modelling. The invention further relates to methods of growing crystals of SorCS2. Furthermore, the invention relates to peptides capable of bindi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SKELDAL, Sune, PEDERSEN, GLERUP, Simon, ALMEIDA, Sergio Eduardo Costa, SKOU THIRUP, Søren, MADSEN, SØNDERGAARD, Peder, VILSTRUP, Joachim Pold
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a SorCS2 crystal structure, the atomic coordinates obtained by X-ray crystallography of same, and their use in molecular modelling. The invention further relates to methods of growing crystals of SorCS2. Furthermore, the invention relates to peptides capable of binding to SorCS2, as well as their use as medicament, for example in the treatment of frontotemporal dementia.