A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE

A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ---, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, an...

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Hauptverfasser:	LI, Wenjun, GUO, Zhixiang, DAI, Meng, HUANG, Yuanyuan, ZHAO, Robert, YANG, Qingliang, CHEN, Binbin, CHEN, Xiaoxiao, ZHAO, Linyao, YE, Hangbo, ZHANG, Lingli, ZHANG, Yu, ZHANG, Xiuzhen, GAI, Shun, LI, Yanhua, ZHENG, Jun, YANG, Yanlei, CHEN, Miaomiao, JIA, Junxiang, ZHOU, Lei, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, JIANG, Xingyan, ZHENG, Xiuhong, LIN, Chen, DU, Yong, KONG, Xiangfei, FAN, Zhongliang, BAI, Lu
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ---, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.