MONITORING AND CONTROL OF BIOPROCESSES

A computer implemented method for monitoring a bioprocess comprising a cell culture in a bioreactor is provided. The method including the steps of: obtaining measurements of the amount of biomass and the amount of one or more metabolites in the bioreactor as a function of bioprocess maturity, using...

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Bibliographische Detailangaben
Hauptverfasser:	TRUNFIO, Nicholas, MCCREADY, Christopher Peter
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY CONTROL OR REGULATING SYSTEMS IN GENERAL CONTROLLING ENZYMOLOGY FUNCTIONAL ELEMENTS OF SUCH SYSTEMS INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS METALLURGY MICROBIOLOGY MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS ORELEMENTS MUTATION OR GENETIC ENGINEERING PHYSICS REGULATING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A computer implemented method for monitoring a bioprocess comprising a cell culture in a bioreactor is provided. The method including the steps of: obtaining measurements of the amount of biomass and the amount of one or more metabolites in the bioreactor as a function of bioprocess maturity, using the measurements to determining one or more metabolic condition variables; using a pre-trained multivariate model to determine the value of one or more latent variables as a function of bioprocess maturity, wherein the multivariate model is a linear model that uses process variables including the metabolic condition variables as predictor variables and maturity as a response variable; comparing the value(s) of the one or more latent variables to one or more predetermined values as a function of maturity; and determining on the basis of the comparison whether the bioprocess is operating normally.