METHOD FOR PREPARING HIGH-PURITY SUGAMMADEX SODIUM

The present invention discloses a method for preparing high-purity sugammadex sodium, which realizes preparation by using inositol phosphate and derivatives thereof. A specific process includes: adding a specific type of protective agent to crude sugammadex sodium, and performing recrystallization u...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Mingming, SHEN, Jianfei, PAN, Pan, WU, Youling, GUO, Hui
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention discloses a method for preparing high-purity sugammadex sodium, which realizes preparation by using inositol phosphate and derivatives thereof. A specific process includes: adding a specific type of protective agent to crude sugammadex sodium, and performing recrystallization under the protection of inert gas to obtain pure sugammadex sodium. The protective agent is selected from inositol phosphate and derivatives thereof, such as inositol hexaphosphate and salts or esters thereof; one or a mixture of two or more of partial degradation products of inositol hexaphosphate, such as inositol pentaphosphate, inositol tetraphosphate, inositol triphosphate, inositol diphosphate, inositol monophosphate, and salts or esters thereof, in any ratio. The method has the advantages of simple operation, high product purity, good safety and less allergic reaction, has good economy and is more suitable for industrial production.