METHOD FOR THE PURIFICATION OF LIPOGLYCOPEPTIDE ANTIBIOTICS

METHOD FOR THE PURIFICATION OF LIPOGLYCOPEPTIDE ANTIBIOTICS

Method for purifying at least one lipoglycopeptide antibiotic comprising the steps of: i) dissolving said at least one lipoglycopeptide antibiotic in an aqueous solution to form a mixture, ii) loading said mixture into a chromatographic column comprising a stationary phase, wherein said stationary p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CAPOZZOLI, Carmine, TERRANEO, Alberto
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Method for purifying at least one lipoglycopeptide antibiotic comprising the steps of: i) dissolving said at least one lipoglycopeptide antibiotic in an aqueous solution to form a mixture, ii) loading said mixture into a chromatographic column comprising a stationary phase, wherein said stationary phase comprises silica functionalized with organic pendants, iii) eluting the mixture loaded in step ii) using an eluent composition comprising a water-soluble organic solvent obtaining eluate fractions, iv) selecting the eluate fractions containing the at least one purified lipoglycopeptide antibiotic.