NEW TRIAZOLE AND TRIAZOLOTHIADIAZINE DERIVATIVES EXERTING CYTOTOXIC AND APOPTOTIC EFFECTS ON A549 CELLS THROUGH AKT INHIBITION

NEW TRIAZOLE AND TRIAZOLOTHIADIAZINE DERIVATIVES EXERTING CYTOTOXIC AND APOPTOTIC EFFECTS ON A549 CELLS THROUGH AKT INHIBITION

The invention is related to new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (2a-j) and 7 new 1,2,4-triazole (3a-g) derivatives and synthesis of these compounds, in vitro anticancer activity studies and molecular docking and in silico ADME studies. It was determined that compounds 2c, 2d, 3b, 3d and 3g o...

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Bibliographische Detailangaben
Hauptverfasser: AKALIN CIFTCI, Gulsen, YILMAZ, Nalan, ALTINTOP, Mehlika Dilek, SEVER, Belgin
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention is related to new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (2a-j) and 7 new 1,2,4-triazole (3a-g) derivatives and synthesis of these compounds, in vitro anticancer activity studies and molecular docking and in silico ADME studies. It was determined that compounds 2c, 2d, 3b, 3d and 3g of the invention exert their cytotoxic and apoptotic effects on A549 human lung adenocarcinoma cell line through Akt inhibition.