MELOXICAM CO-CRYSTAL COMPOSITIONS

The solubility and bioavailability properties of meloxicam can be improved by preparing compositions of meloxicam co-crystals and reducing the particle size of (e.g., "nanosizing") co-crystals. Such compositions with improved dissolution pharmacokinetic properties can be prepared by granul...

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Bibliographische Detailangaben
Hauptverfasser:	DIXIT, Akhilesh, HUMMEL, Matthew A, RACKLEY, Russ, ALLAN, Richard, ANTARKAR, Amit, SMITH, Jeffrey P, CHAKRABORTY, Santanu, JAISWAL, Ashish, SHAW, Andrew, KAKARIA, Ritesh, DESHMUKH, Abhijit, PATIL, Pankaj
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The solubility and bioavailability properties of meloxicam can be improved by preparing compositions of meloxicam co-crystals and reducing the particle size of (e.g., "nanosizing") co-crystals. Such compositions with improved dissolution pharmacokinetic properties can be prepared by granulation and blending the co-crystals with extragranular excipients to provide oral solid dosage forms. As a result of the improved properties of the meloxicam oral dosage forms, the compositions may be useful for the treatment of pain, including acute pain.