DETECTION OF CARDIAC TROPONIN OR BIOLOGICAL MARKERS VIA SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR USING A WET-DRY BIOANALYTICAL TECHNIQUE

DETECTION OF CARDIAC TROPONIN OR BIOLOGICAL MARKERS VIA SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR USING A WET-DRY BIOANALYTICAL TECHNIQUE

The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay device and sensor system; maintaining the functionalized detection lane of the S...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: THOMAS, Marlon, SHACHAR, Yehoshua
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay device and sensor system; maintaining the functionalized detection lane of the SAW sensor dry until the sample is fluidically disposed in the detection lane; fluidically disposing the sample in the functionalized detection lane; removing fluid the functionalized detection lane to concentrate the sample in the functionalized detection lane to increase the probability of a specific antibody-antigen interaction; washing the functionalized detection lane so that substantially only the specific antigen-antibody interaction remains in the functionalized detection lane; removing fluid from the functionalized detection lane again; and measuring concentration of the sample while the functionalized detection lane is fluid-free.