COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or car...

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Bibliographische Detailangaben
Hauptverfasser: HERTZ, Nicholas, Thomas, CHIN, Randall, Marcelo, DEVITA, Robert, BARTHOLOMEUS, Johan, JOHNSTONE, Shawn, DE ROULET, Daniel
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.