A CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-METHYL N-((2'-CYANO-[1,1'-BIPHENYL]-4-YL)METHYL)-N-PENTANOYLVALINATE IN A FLOW REACTOR

A CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-METHYL N-((2'-CYANO-[1,1'-BIPHENYL]-4-YL)METHYL)-N-PENTANOYLVALINATE IN A FLOW REACTOR

The present invention relates to a continuous process for the preparation of valsartan precursor (S)-methyl N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoylvalinate from (S)-methyl ((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)valinate hydrochloride by N-acylation with valeryl chlo...

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Bibliographische Detailangaben
Hauptverfasser: Ruzic, Milo, Regina, Blaz, Zupancic, Silvo, Bitenc, Marko, Svetelj, Jure, Plazl, Igor, Znidarsic Plazl, Polona
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention relates to a continuous process for the preparation of valsartan precursor (S)-methyl N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoylvalinate from (S)-methyl ((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)valinate hydrochloride by N-acylation with valeryl chloride carried out in a flow reactor.