ANTIBODY-DRUG CONJUGATES INCLUDING ANTIBODY AGAINST HUMAN DLK1, AND USE THEREOF

ANTIBODY-DRUG CONJUGATES INCLUDING ANTIBODY AGAINST HUMAN DLK1, AND USE THEREOF

The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of...

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Bibliographische Detailangaben
Hauptverfasser: KIM, Sung Min, KIM, Hyoung Rae, YOON, Sunha, PARK, Yun-Hee, PARK, Bum-Chan, PARK, Jae Eun, LEE, Chang Sun, BAEK, Juyuel, PARK, Young Woo, CHOI, Min Ji, KIM, Yong Zu, LEE, Sang Pil, JANG, Tae Ik, CHAE, Jeiwook, SHIN, Ji-young, PARK, Chang Sik, LEE, Kun Jung, LEE, Ju Young, CHOI, Yunseon, LEE, Hyeun Joung, LEE, Jisu, SONG, Ho Young
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.