MODIFIED GIP PEPTIDE ANALOGUES

MODIFIED GIP PEPTIDE ANALOGUES

Disclosed are glucose-dependent insulinotropic peptide (GIP)-derived peptide analogues which are antagonists of the GIP receptor. These GIP peptide analogues are modified by comprising one or more individual amino acid substitutions and are fatty acid conjugated with/without a linker, so to have imp...

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Bibliographische Detailangaben
Hauptverfasser: SIVERTSEN, Bjørn, Behrens, ROSENKILDE, Mette, Marie, RIBER, Ditte, SPARRE-ULRICH, Alexander, Hovard
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Disclosed are glucose-dependent insulinotropic peptide (GIP)-derived peptide analogues which are antagonists of the GIP receptor. These GIP peptide analogues are modified by comprising one or more individual amino acid substitutions and are fatty acid conjugated with/without a linker, so to have improved antagonistic activity and improved pharmacokinetic profile.