NANO-DRY-MELTING

Disclosed herein is a method for the preparation of an amorphous solid dispersion (ASD) comprising the steps of providing an aqueous suspension comprising nano-particles having a solubility in the aqueous suspension of less than 10g/l, water and at least one polymer, nano-dry-melting of the aqueous suspension comprising nano-particles for a time span between 0.1 seconds and 300 seconds, at a temperature betweena) 20K below the glass transition temperature as determined with DSC according to DIN EN ISO 11357-2 at a heating rate of 10 K/min of the solid components of the aqueous suspension comprising nano-particles or 20K below the glass transition temperature of the at least one polymer, depending on what is higher,b) the decomposition temperature of the at least one polymer or the decomposition temperature of the nano-particles, depending which is lower to form the amorphous solid dispersion.