METHODS FOR SYNTHESIS OF RADIONUCLIDE COMPLEX

The present disclosure relates to the synthesis of radionuclide complex solutions, in particular for their use in the commercial production of radioactive drug substances, for diagnostic and/or therapeutic purposes. In particular, the synthesis method comprises the following steps in the following order:a. providing a radionuclide precursor solution into a first vial,b. transferring the radionuclide precursor solution into a reactor,c. providing a reaction buffer solution into said first vial containing residual radionuclide precursor solution,d. transferring the buffer reaction solution and residual radionuclide precursor solution from said first vial into the reactor,e. transferring a peptide solution comprising the somatostatin receptor binding peptide linked to a chelating agent, into the reactor,f. reacting the somatostatin receptor binding peptide linked to a chelating agent with said radionuclide in the reactor to obtain the radionuclide complex,g. recovering said radionuclide complex.