2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS

The invention provides compound that inhibit or modulate the activity of p70S6 kinase, the compounds being of the formula (1):or a salt, tautomer or N-oxide thereof; wherein:one of Y and Z is R3 and the other is Ar2;Q1 is an optionally substituted C1-8 alkylene group; and wherein a carbon atom of the C1-8 alkylene group may optionally be replaced by a cyclopropane-1,1-diyl or cyclobutane-1,1-diyl group provided that the total number of carbon atoms in an alkylene group containing such a replacement does not exceed 8;Q2 is a bond or an optionally substituted C1-8 alkylene groupR1 is selected from hydrogen, NRxRy and a group Cy1;Rx and Ry are each is selected from hydrogen, C1-4 hydrocarbyl or hydroxy-C1-4 hydrocarbyl; or NRxRy forms an optionally substituted 4 to 7-membered heterocyclic ring;Cy1 is an optionally substituted C-linked 3 to 7 membered monocyclic nonaromatic carbocyclic or heterocyclic;R2 and R4 are each is selected from hydrogen, fluorine, chlorine, optionally substituted C1-2 alkyl and optionally substituted C1-2 alkoxy;R3 is selected from hydrogen, fluorine, chlorine, optionally substituted C1-2 alkyl and optionally substituted C1-2 alkoxy;Ar1 is an optionally substituted monocyclic 5 or 6-membered aryl or heteroaryl ring; andAr2 is an optionally substituted bicyclic 8 to 11-membered heteroaryl group.The compounds are useful in medicine, for example in the treatment of a disease or condition selected from cancers, neurodevelopmental diseases and neurodegenerative diseases.