METHOD OF MAKING RELEASABLE POLYMERIC REAGENTS

The instant disclosure provides (among other things) improved methods of preparing fluorenyl-based polymeric reagents, methods of recovering and purifying such polymeric reagents, methods of reducing unwanted impurities in a fluorenyl-based polymeric reagent, fluorenyl-based polymeric reagents prepa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KOZLOWSKI, Antoni, CULBERTSON, Sean, M, MCMANUS, Samuel, P, SOMU, Venkata
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The instant disclosure provides (among other things) improved methods of preparing fluorenyl-based polymeric reagents, methods of recovering and purifying such polymeric reagents, methods of reducing unwanted impurities in a fluorenyl-based polymeric reagent, fluorenyl-based polymeric reagents prepared by the methods described herein, and conjugates prepared by reaction with fluorenyl-based polymeric reagents prepared by the methods described herein.