TWO-GENE VECTORS FOR GENERATING CAR-T CELLS AND USES THEREOF

TWO-GENE VECTORS FOR GENERATING CAR-T CELLS AND USES THEREOF

The present invention provides two-gene retroviral vector compositions comprising polynucleotides encoding an anti-CD7 chimeric activating receptor (CAR) and polynucleotides encoding an anti-CD7 protein expression blocker. Also provided are methods of producing and methods of using such compositions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TAN, Ying, Xim, ROBINSON, Murray, ISMAIL, Rizal, LEE, Yunqin
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention provides two-gene retroviral vector compositions comprising polynucleotides encoding an anti-CD7 chimeric activating receptor (CAR) and polynucleotides encoding an anti-CD7 protein expression blocker. Also provided are methods of producing and methods of using such compositions in cancer therapy.