SOLID-PHASE N-TERMINAL PEPTIDE CAPTURE AND RELEASE

SOLID-PHASE N-TERMINAL PEPTIDE CAPTURE AND RELEASE

Provided herein are rapid and reversible methods to non-specifically immobilize peptides and proteins irrespective of their sequence, as well as small molecules, on a solid support to allow for manipulations of and reactions with these molecules in a manner that does not require purification between...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SWAMINATHAN, Jagannath, HOWARD, Cecil, J., II, BARDO, Angela, M, FLOYD, Brendan M, MARCOTTE, Edward, REUTHER, James, ANSLYN, Eric
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Provided herein are rapid and reversible methods to non-specifically immobilize peptides and proteins irrespective of their sequence, as well as small molecules, on a solid support to allow for manipulations of and reactions with these molecules in a manner that does not require purification between steps, which increases sample yield and reduces the quantity of starting material required.