METHODS AND SYSTEMS FOR ASSESSING MICROSATELLITE INSTABILITY

The invention disclosed herein generally relates to methods of assessing microsatellite instability in a subject. In an aspect, the present disclosure provides a computer-implemented method of assessing microsatellite instability of a subject, comprising: obtaining a quantitative measure of a plural...

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Bibliographische Detailangaben
Hauptverfasser:	PETERMAN, Neil, SRIVAS, Rohith Kannappan, ROBERTSON, Alexander De Jong, TEZCAN, Haluk, LAMBERT, Nicole Jacinda, YALAMANCHILI, Ram
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention disclosed herein generally relates to methods of assessing microsatellite instability in a subject. In an aspect, the present disclosure provides a computer-implemented method of assessing microsatellite instability of a subject, comprising: obtaining a quantitative measure of a plurality of microsatellite repeat elements from a blood sample of a subject; processing the plurality of quantitative measures to obtain a statistical measure of deviation of the plurality of quantitative measures; and detecting a presence of the microsatellite instability (MSI) of the subject when the statistical measure of deviation of the plurality of quantitative measures satisfies a predetermined criterion, or detecting an absence of the microsatellite instability (MSI) of the subject when the statistical measure of deviation of the plurality of quantitative measures does not satisfy the predetermined criterion.