ACELLULAR ORGANS, AND METHODS OF PRODUCING THE SAME

Provided are methods of producing an acellular organ. The method includes the steps of, subjecting an organ derived from an animal to a static supercritical fluid (SCF) treatment followed by a dynamic SCF treatment. Optionally, the method of the present disclosure further includes a hypertonic and a...

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Bibliographische Detailangaben
Hauptverfasser: PERIASAMY, Srinivasan, KUO, Jer-Cheng, WEI, Chao-Yi, HSIEH, Dar-Jen, LAI, Yi-Ping, CHAO, Chao-Chin
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Provided are methods of producing an acellular organ. The method includes the steps of, subjecting an organ derived from an animal to a static supercritical fluid (SCF) treatment followed by a dynamic SCF treatment. Optionally, the method of the present disclosure further includes a hypertonic and a hypotonic treatments prior to the static SCF treatment, and/or a neutralizing treatment after the dynamic SCF treatment. Also disclosed herein are acellular organs produced by the present method.