COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS

COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS

Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.

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Bibliographische Detailangaben
Hauptverfasser: ASHMINOVA, Vania, BAEUERLE, Patrick Alexander, DING, Jian, LOFGREN, Michael, HOFMEISTER, Robert
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are T cell receptor (TCR) fusion proteins (TFPs) having specificity for more than one tumor cell associated antigen, T cells engineered to express one or more TFP, and methods of use thereof for the treatment of diseases, including cancer.