CD73 INHIBITORS

CD73 INHIBITORS

Compounds, such as compounds having Formula (I):wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compoun...

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Bibliographische Detailangaben
Hauptverfasser: BEATTY, Joel, MANDAL, Debashis, LELETI, Manmohan Reddy, DREW, Samuel Lawrie, LAWSON, Kenneth V, THOMAS-TRAN, Rhiannon, LINDSEY, Erick Allen, DEBIEN, Laurent Pierre Paul, JEFFREY, Jenna Leigh, FOURNIER, Jeremy, TRAN, Anh Thu, GRANGE, Rebecca Louise, POWERS, Jay Patrick, YAN, Xuelei, JACOB, Steven Donald
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds, such as compounds having Formula (I):wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.