BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS
The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): ...
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| creator | ISHIHARA, Mitsuko NOZAKI, Emi NAITO, Katsuyuki AKAHOSHI, Eiichi SARUWATARI, Saeko |
| description | The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R): -LR1-C(=O)-O-LR2 (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2): -CH2-CH=CH-(CH2)r2-H (1-R2)where r2 is an integer of 1 to 10. |
| format | Patent |
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SARUWATARI, Saeko</creatorcontrib><description>The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R): -LR1-C(=O)-O-LR2 (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2): -CH2-CH=CH-(CH2)r2-H (1-R2)where r2 is an integer of 1 to 10.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240424&DB=EPODOC&CC=EP&NR=3842412B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240424&DB=EPODOC&CC=EP&NR=3842412B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ISHIHARA, Mitsuko</creatorcontrib><creatorcontrib>NOZAKI, Emi</creatorcontrib><creatorcontrib>NAITO, Katsuyuki</creatorcontrib><creatorcontrib>AKAHOSHI, Eiichi</creatorcontrib><creatorcontrib>SARUWATARI, Saeko</creatorcontrib><title>BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS</title><description>The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R): -LR1-C(=O)-O-LR2 (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2): -CH2-CH=CH-(CH2)r2-H (1-R2)where r2 is an integer of 1 to 10.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeod5gIu2rpwmybTOpBmQjJVXJUicSVaqPfHIB7A1f_89_jrYmmIDXZBGdVYBEueTISWAxi0dMZwBW5BackdNPeeB5cFcsIgQ589jdbGLwoUyXUgF4a8Z4YgGIRUPlE9OYYu8ODjtljdp8eSdr_cFNCi6NM-za8xLfN0S8_0HtHXx0N1KKumrP9QPiKtOHc</recordid><startdate>20240424</startdate><enddate>20240424</enddate><creator>ISHIHARA, Mitsuko</creator><creator>NOZAKI, Emi</creator><creator>NAITO, Katsuyuki</creator><creator>AKAHOSHI, Eiichi</creator><creator>SARUWATARI, Saeko</creator><scope>EVB</scope></search><sort><creationdate>20240424</creationdate><title>BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS</title><author>ISHIHARA, Mitsuko ; NOZAKI, Emi ; NAITO, Katsuyuki ; AKAHOSHI, Eiichi ; SARUWATARI, Saeko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3842412B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ISHIHARA, Mitsuko</creatorcontrib><creatorcontrib>NOZAKI, Emi</creatorcontrib><creatorcontrib>NAITO, Katsuyuki</creatorcontrib><creatorcontrib>AKAHOSHI, Eiichi</creatorcontrib><creatorcontrib>SARUWATARI, Saeko</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ISHIHARA, Mitsuko</au><au>NOZAKI, Emi</au><au>NAITO, Katsuyuki</au><au>AKAHOSHI, Eiichi</au><au>SARUWATARI, Saeko</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS</title><date>2024-04-24</date><risdate>2024</risdate><abstract>The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R): -LR1-C(=O)-O-LR2 (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2): -CH2-CH=CH-(CH2)r2-H (1-R2)where r2 is an integer of 1 to 10.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS |
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