BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS

BIODEGRADABLE LIPIDS FOR DELIVERY OF ACTIVE COMPOUNDS INTO TUMOR CELLS COMPRISING TWO OR MORE TERTIARY AMINO GROUPS

The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1):         Q-CHR2     (1)whereinQ is represented by the following formula (1-Q):       ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ISHIHARA, Mitsuko, NOZAKI, Emi, NAITO, Katsuyuki, AKAHOSHI, Eiichi, SARUWATARI, Saeko
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1):         Q-CHR2     (1)whereinQ is represented by the following formula (1-Q):         RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-*     (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R):         -LR1-C(=O)-O-LR2     (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2):         -CH2-CH=CH-(CH2)r2-H     (1-R2)where r2 is an integer of 1 to 10.