IMPROVED PROCOAGULANT ANTIBODIES

The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding th...

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Bibliographische Detailangaben
Hauptverfasser:	HARNDAHL, Mikkel, Nors, JOHANSSON, Eva, ZHOU, Rong, YANG, Zhiru, THORN, Karina, GREISEN, Per, J, ZHU, Haisun, JOHNSEN, Laust ,Bruun, SVENSSON, Anders, CHEN, Jianhe, ØSTERGAARD, Henrik, HANSEN, Bjarne, Gram, RASCH, Morten, Grønbech
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.