COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE

The present invention relates to combinations comprising a positive allosteric modulator ("PAM") of metabotropic glutamatergic receptor subtype 2 ("mGluR2") or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic recepto...

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Hauptverfasser: TWYMAN, Roy, E, PYPE, Stefan, Maria, Christiaan, TRABANCO-SUÁREZ, Andrés, Avelino, WHITE, H., Steve, VAN OSSELAER, Nancy, Eulalie, Sylvain, CID-NÚÑEZ, José, Maria, LAVREYSEN, Hilde, BONE, Roger, Francis, KLEIN, Brian, D, CEUSTERS, Marc
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to combinations comprising a positive allosteric modulator ("PAM") of metabotropic glutamatergic receptor subtype 2 ("mGluR2") or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A ("SV2A") ligand.