PURIFICATION PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

PURIFICATION PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

The present application relate to a purification process for preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof having less than 0.15% or substantially free or free from one or more impurities. The present application also provide acid addition salt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KONING, Pieter David de, JACKSON, Philip Mark, MAHONEY, Thomas, MADIVADA, Lokeswara Rao, ORUGANTI, Srinivas, ACHANTA, Srinivas, MEEK, Graham Andrew, BUDHDEV, Rajeev Rehani
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present application relate to a purification process for preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof having less than 0.15% or substantially free or free from one or more impurities. The present application also provide acid addition salts of eribulin and process for preparation thereof.