HIGH-AFFINITY, ISOFORM-SELECTIVE TGF?1 INHIBITORS AND USE THEREOF

HIGH-AFFINITY, ISOFORM-SELECTIVE TGF?1 INHIBITORS AND USE THEREOF

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

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Bibliographische Detailangaben
Hauptverfasser: CHAPRON, Christopher, WAWERSIK, Stefan, STEIN, Caitlin, BUCKLER, Alan, JACKSON, Justin, W, COOPER, Anthony, LIN, Susan, SCHURPF, Thomas, DAGBAY, Kevin, B, CAPILI, Allan, DATTA, Abhishek, SALOTTO, Matthew, MARTIN, Constance, AVERY, Andrew, LITTLEFIELD, Christopher, CARVEN, Gregory, J
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.