ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodi...

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Hauptverfasser: LOVELACE, Thomas, Claiborne, LEE, Christopher, McKinnon, MOORE, Joseph, Alexander III, KIRSCHNER, Daniel, Logan
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
COMPOUNDS THEREOF
HUMAN NECESSITIES
HYGIENE
INORGANIC CHEMISTRY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NON-METALLIC ELEMENTS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator LOVELACE, Thomas, Claiborne
LEE, Christopher, McKinnon
MOORE, Joseph, Alexander III
KIRSCHNER, Daniel, Logan
description Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.
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subjects CHEMISTRY
COMPOUNDS THEREOF
HUMAN NECESSITIES
HYGIENE
INORGANIC CHEMISTRY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NON-METALLIC ELEMENTS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF
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