ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

ANHYDROUS SODIUM THIOSULFATE AND FORMULATIONS THEREOF

Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodi...

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Hauptverfasser: LOVELACE, Thomas, Claiborne, LEE, Christopher, McKinnon, MOORE, Joseph, Alexander III, KIRSCHNER, Daniel, Logan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
COMPOUNDS THEREOF
HUMAN NECESSITIES
HYGIENE
INORGANIC CHEMISTRY
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NON-METALLIC ELEMENTS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.