HUMAN ANTI-AAV2 CAPSID POLYCLONAL ANTIBODY EPITOPES

HUMAN ANTI-AAV2 CAPSID POLYCLONAL ANTIBODY EPITOPES

Human anti-AAV capsid polyclonal antibody conformational epitopes including those of neutralizing antibodies are provided. The epitopes can be recognized by human anti-AAV2 or other AAV strain-derived capsid polyclonal antibodies. One or more of the epitopes may be mutated to form AAV2 and other AAV...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ADACHI, Kei, NAKAI, Hiroyuki, CHANG, Xiao Lan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
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PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
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Beschreibung
Zusammenfassung:Human anti-AAV capsid polyclonal antibody conformational epitopes including those of neutralizing antibodies are provided. The epitopes can be recognized by human anti-AAV2 or other AAV strain-derived capsid polyclonal antibodies. One or more of the epitopes may be mutated to form AAV2 and other AAV strain-derived capsids that can escape antibody neutralization. Methods of identifying human anti-AAV capsid polyclonal antibody conformational epitopes are also provided.