A DOSING REGIME AND FORMULATIONS FOR TYPE B ADENOVIRUSES

A DOSING REGIME AND FORMULATIONS FOR TYPE B ADENOVIRUSES

The present disclosure provides a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B for use in treatment of a human patient by intravenously administering a treatment cycle with multiple doses each in the range 1 x 1010 to 1 x1013 viral particles administered over a...

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Bibliographische Detailangaben
Hauptverfasser: WILKINSON BLANC, Christine, BEADLE, John, FISHER, Kerry, David
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B for use in treatment of a human patient by intravenously administering a treatment cycle with multiple doses each in the range 1 x 1010 to 1 x1013 viral particles administered over a period 1 to 90 minutes, wherein a single treatment cycle is 14 days or less and said cycle comprising a first dose on day 1..