METHOD TO DISTINGUISH TUMOR SUPPRESSIVE FOXO ACTIVITY FROM OXIDATIVE STRESS

The present invention relates to a kit of parts for the detection of certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical s...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DE STOLPE, Anja, Velter, Rick, VERHAEGH, Wilhelmus Franciscus Johannes, VAN OOIJEN, Hendrik Jan, Akse, Martijn Theodorus Lambert
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a kit of parts for the detection of certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to the use of the kit in inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.