4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)

Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in...

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Hauptverfasser: SHEPHERD, Steven David, O'DOWD, Colin, HARRISON, Timothy, TREDER, Adam Piotr, BURKAMP, Frank, ROUNTREE, James Samuel Shane, COSTA, Joana Rita Castro, WHITEHEAD, Steven Kristopher, PROCTOR, Lauren Emma
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.