MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE

MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE

Compounds of Formula (I) are disclosed:wherein A1, R1, R2, R3, R4, and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by ad...

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Hauptverfasser: PIZZONERO, Mathieu Rafaël, COUTY, Sylvain, KYM, Philip R, PICOLET, Olivier Laurent, DESROY, Nicolas, LIU, Bo, SEARLE, Xenia B, VAN DER PLAS, Steven Emiel, MALAGU, Karine Fabienne, MAI, Thi Thu Trang, WANG, Xueqing, GFESSER, Gregory A, YEUNG, Ming C, BOGDAN, Andrew, MERAYO MERAYO, Nuria, ALTENBACH, Robert J, HOUSSEMAN, Christopher Gaëtan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of Formula (I) are disclosed:wherein A1, R1, R2, R3, R4, and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering the compounds.