BISPECIFIC ANTIBODY FOR ICOS AND PD-L1

BISPECIFIC ANTIBODY FOR ICOS AND PD-L1

Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCCOURT, Matthew John, TUNA, Mihriban, WOLLERTON VAN HORCK, Francisca, ARKINSTALL, Stephen John, BADR, Fadi, FIEHLER, Ryan, CAMPBELL, Jamie Iain, AKELE, Frederik, SAINSON, Richard Charles Alfred, FAROUDI, Mustapha
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1.