NOVEL SPIROBICYCLIC ANALOGUES

The present invention relates to novel spirobicyclic analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MEERPOEL, Lieven, BREHMER, Dirk, WU, Tongfei, PANDE, Vineet, THURING, Johannes Wilhelmus John F, DENMARK, Scott E, VERNIEST, Guido Alfons F, SUN, Weimei, VERHOEVEN, Jonas
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to novel spirobicyclic analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.