CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS
Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE...
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| creator | CHAUMET, Alexandre BARD, Frederic TING, Trinda Anne |
| description | Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE comprises PE Domains la and I I, and the c-Myc inhibitor is H1 peptide derived from helix 1 carboxylic region of c-Myc. Also disclosed herein are pharmaceutical compositions comprising chimeric fusion proteins, methods of delivering, methods of preparing, and use of chimeric fusion proteins to prevent or treat a c-Myc dependent cancer. |
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In particular, the tPE comprises PE Domains la and I I, and the c-Myc inhibitor is H1 peptide derived from helix 1 carboxylic region of c-Myc. Also disclosed herein are pharmaceutical compositions comprising chimeric fusion proteins, methods of delivering, methods of preparing, and use of chimeric fusion proteins to prevent or treat a c-Myc dependent cancer.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201007&DB=EPODOC&CC=EP&NR=3717506A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201007&DB=EPODOC&CC=EP&NR=3717506A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAUMET, Alexandre</creatorcontrib><creatorcontrib>BARD, Frederic</creatorcontrib><creatorcontrib>TING, Trinda Anne</creatorcontrib><title>CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS</title><description>Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE comprises PE Domains la and I I, and the c-Myc inhibitor is H1 peptide derived from helix 1 carboxylic region of c-Myc. Also disclosed herein are pharmaceutical compositions comprising chimeric fusion proteins, methods of delivering, methods of preparing, and use of chimeric fusion proteins to prevent or treat a c-Myc dependent cancer.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBz9vD0dQ3ydFbw9fdxdQ71cVVw8w9SCHEMcncN8fRzV3DW9Y10VvD0U3B29fEJ5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BxuaG5qYGZo6GxkQoAQB3kyUA</recordid><startdate>20201007</startdate><enddate>20201007</enddate><creator>CHAUMET, Alexandre</creator><creator>BARD, Frederic</creator><creator>TING, Trinda Anne</creator><scope>EVB</scope></search><sort><creationdate>20201007</creationdate><title>CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS</title><author>CHAUMET, Alexandre ; BARD, Frederic ; TING, Trinda Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3717506A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAUMET, Alexandre</creatorcontrib><creatorcontrib>BARD, Frederic</creatorcontrib><creatorcontrib>TING, Trinda Anne</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAUMET, Alexandre</au><au>BARD, Frederic</au><au>TING, Trinda Anne</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS</title><date>2020-10-07</date><risdate>2020</risdate><abstract>Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. 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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS |
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